Tumor Uptake of Tc-HL91 and Tc-PnAO-Nitroimidazole in an Animal Model of Non-small Cell Lung Cancer
نویسندگان
چکیده
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taichung, Taiwan Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan Department of Nuclear Science, National Tsing Hua University, Hsinchu, Taiwan Institute of Nuclear Energy Research, Lung-Tan, Taiwan Department of Medical Imaging and Radiological Sciences, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan
منابع مشابه
Accumulation of Tc-99m HL91 in tumor hypoxia: in vitro cell culture and in vivo tumor model.
Hypoxic cells within a tumor can account, in part, for resistance to radiotherapy and chemotherapy. Indeed, the oxygenation status has been shown to be a prognostic marker for the outcome of therapy. The purpose of this study was to determine whether Tc-99m HL91 (HL91), a noninvasive imaging tracer, detects tumor hypoxia in vitro in cell culture and in vivo in a tumor model. Uptake of HL91 in v...
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The nitro group of 2-nitroimidazole (NIM) enters the tumor cells and is bioreductively activated and fixed in the hypoxia cells. 1,4,8,11-tetraazacyclotetradecane (N4) has shown to be a stable chelator for (99m)Tc. The present study was aimed to develop (99m)Tc-cyclam-2-nitroimidazole ((99m)Tc-N4-NIM) for tumor hypoxia imaging. N4-NIM precursor was synthesized by reacting N4-oxalate and 1,3-dib...
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Received 2/6/2002; revised 3/15/2002; accepted 4/17/2002. For correspondence or reprints contact: Shyh-Jen Wang, M.D., Department of Nuclear Medicine, Taichung Veterans General Hospital, 160 Section 3, Taichung Harbor Road, Taichung 407, Taiwan, R.O.C., Tel: (886)4-23741349, Fax: (886)423741348, E-mail: [email protected] Background: Many malignant tumors are characterized by perfusion h...
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